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76,185 In pancreatic -cells, it mitigates ER stress and promotes insulin secretion

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Conversion of 4-hydroxyproline to oxalate begins with its oxidation to 1 -pyrroline-3-hydroxy-5-carboxylate by proline dehydrogenase 2 (encoded by the PRODH2 gene)

doi: 10.1038/nri.2016.147 [DOI] [PMC free article] [PubMed] [Google Scholar] 80.Fuchs TA, Abed U, Goosmann C, et al